Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25− lymphocytes - Hospices Civils de Lyon Accéder directement au contenu
Article Dans Une Revue Critical Care Medicine Année : 2004

Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25− lymphocytes

Résumé

Objective: The elevation of the percentage of regulatory CD4+CD25+ T lymphocytes (Treg) has been recently described during septic shock. The objective of the present study was to investigate whether this increased percentage was due to Treg proliferation. Design: Observational study. Setting: Adult intensive care units in a university hospital. Subjects: Patients with septic shock (n = 54) and healthy individuals (n = 30). Interventions: None. Measurements and Main Results: In patients, we first confirmed the increased percentage of Treg among CD4+ lymphocytes in comparison with healthy individuals. Surprisingly, regarding absolute counting, we demonstrated that both T CD4+ lineages (CD25+ and CD25-) were diminished immediately after the onset of shock. Then, whereas Treg returned rapidly to healthy donors values, CD4+CD25- T lymphocytes remained dramatically reduced. Finally, Foxp3 (Treg-related gene) messenger RNA quantification enabled us to definitively rule out a lack of proliferation since it was not increased during shock. Conclusion: The increased percentage of Treg after shock is due not to their proliferation but to a decrease in CD4+CD25- T lymphocyte number. We hypothesize that it might be due to a resistance of Treg to apoptosis processes occurring during septic shock.
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hal-04066434 , version 1 (12-04-2023)

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Fabienne Venet, Alexandre Pachot, Anne-Lise Debard, Julien Bohé, Jacques Bienvenu, et al.. Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25− lymphocytes. Critical Care Medicine, 2004, 32 (11), pp.2329-2331. ⟨10.1097/01.ccm.0000145999.42971.4b⟩. ⟨hal-04066434⟩

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